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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CHAT All Species: 0.91
Human Site: Y203 Identified Species: 1.67
UniProt: P28329 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P28329 NP_066266.3 748 82536 Y203 E Y W L N D M Y L N N R L A L
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001109211 626 70697 S119 Q P V V I C S S P G V M L P K
Dog Lupus familis XP_543902 686 76910 G179 F A A S L I S G V L H Y K T M
Cat Felis silvestris
Mouse Mus musculus Q03059 641 71834 G134 F A A S L I S G V L S Y K A L
Rat Rattus norvegicus P32738 640 71845 G133 F A A C L I S G V L S Y K T L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509108 643 72737 G136 F A A H L I S G V L D Y K A L
Chicken Gallus gallus Q90YJ9 640 72605 G133 F A A N L I S G V Q D Y K A L
Frog Xenopus laevis Q7ZXE1 659 74538 I152 P E Y N S Q L I R A T N M T V
Zebra Danio Brachydanio rerio B2ZGJ1 637 71821 L130 A N L I S G V L E Y K A L I D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P07668 721 81310 L195 V A H F A A R L L D G I L S H
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P32756 627 71299 I120 F E T K E D H I K Y T A L L T
Sea Urchin Strong. purpuratus XP_001185550 675 75787 L168 A K L I S G I L D Y K V V I D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P32796 670 77223 M163 V S Y F Y S H M P L P N H L S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 37.8 77.9 N.A. 74.7 74.7 N.A. 68.4 66 24 57 N.A. 37.5 N.A. 29.2 46.3
Protein Similarity: 100 N.A. 55.7 82.4 N.A. 79.1 79 N.A. 76.5 74 40.6 68.8 N.A. 56.1 N.A. 45.1 62.4
P-Site Identity: 100 N.A. 6.6 0 N.A. 13.3 6.6 N.A. 13.3 13.3 0 6.6 N.A. 13.3 N.A. 13.3 0
P-Site Similarity: 100 N.A. 20 20 N.A. 26.6 20 N.A. 26.6 26.6 33.3 26.6 N.A. 26.6 N.A. 13.3 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 27 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 44.2 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 16 47 39 0 8 8 0 0 0 8 0 16 0 31 0 % A
% Cys: 0 0 0 8 0 8 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 16 0 0 8 8 16 0 0 0 16 % D
% Glu: 8 16 0 0 8 0 0 0 8 0 0 0 0 0 0 % E
% Phe: 47 0 0 16 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 16 0 39 0 8 8 0 0 0 0 % G
% His: 0 0 8 8 0 0 16 0 0 0 8 0 8 0 8 % H
% Ile: 0 0 0 16 8 39 8 16 0 0 0 8 0 16 0 % I
% Lys: 0 8 0 8 0 0 0 0 8 0 16 0 39 0 8 % K
% Leu: 0 0 16 8 39 0 8 24 16 39 0 0 39 16 39 % L
% Met: 0 0 0 0 0 0 8 8 0 0 0 8 8 0 8 % M
% Asn: 0 8 0 16 8 0 0 0 0 8 8 16 0 0 0 % N
% Pro: 8 8 0 0 0 0 0 0 16 0 8 0 0 8 0 % P
% Gln: 8 0 0 0 0 8 0 0 0 8 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 8 0 8 0 0 8 0 0 0 % R
% Ser: 0 8 0 16 24 8 47 8 0 0 16 0 0 8 8 % S
% Thr: 0 0 8 0 0 0 0 0 0 0 16 0 0 24 8 % T
% Val: 16 0 8 8 0 0 8 0 39 0 8 8 8 0 8 % V
% Trp: 0 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 8 16 0 8 0 0 8 0 24 0 39 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _